Blockade of Fatty Acid Synthase Triggers Significant Apoptosis in Mantle Cell Lymphoma
Figure 7
FASN inhibition decreased β-catenin expression.
The MCL cell line Mino was treated with Orlistat (A) or siRNA (B) to inhibit or knock-down FASN, respectively. The β-catenin protein expression was determined by western blot after 48 hours of treatment. FASN inhibition by either Orlistat or siRNA substantially decreased the protein expression of β-catenin. Triplicate experiments were performed.