Amplified Genes May Be Overexpressed, Unchanged, or Downregulated in Cervical Cancer Cell Lines
Figure 7
Genome amplification and deregulation of gene expression in Chr 1q.
Panel A shows the copy number log2 ratio of SNPs investigated in Chr 1 by the 100 K SNP microarray in HeLa, CaSki, SiHa, and CaLo. Panels B to D show the fold change of gene expression of genes evaluated by the ST1.0 expression microarray located at MRRs 1-8, 1-9, 1-14 and 1-15. The genes are ordered according to position in the genome. For panel F, the mean ± S.D. of the log2 ratio signal of 110 SNPs located in the MRR-15 was plotted. In panel G is shown the copy number of PARP1 gene calculated by qPCR in triplicate experiments. See the legend of Figure 2 for further information.