Adaptive Models for Gene Networks
Figure 1
System identification of the p53-MDM2 gene network.
(a) Models describe relationships between measured input and output data. They are subject to three types of uncertainty: system uncertainty (e1), environmental uncertainty (e2), and measurement uncertainty (e3). (b) An adaptive filter iteratively adjusts the model parameters based on the error between the measured and estimated data. (c) p53 and MDM2 levels oscillate after radiation-induced DNA damage. (d) The best time-invariant ARX model (na = 1, nb = 3, nk = 2) only has a Best Fit score of 12.9%.