Curcumin Promotes A-beta Fibrillation and Reduces Neurotoxicity in Transgenic Drosophila
Figure 1
Curcumin affects Drosophila longevity as a function of genotype.
Survival trajectories of transgenic C155-Gal4 Drosophila for different curcumin treatments indicated by: no curcumin added (black lines), 1, 10, and 100 µg curcumin per g yeast paste represented in yellow, orange, and red lines respectively. (A) Control flies showed a concentration dependent decrease in lifespan upon curcumin treatment. (B) Aβ1–40 expressing flies showed reduced survival times when fed intermediate and high curcumin concentrations. (C) Single insert Aβ1–42 expressing flies showed increased survival when treated with low and intermediate curcumin concentrations. (D) Double insert Aβ1–42 expressing flies showed an increased survival for low and intermediate curcumin concentrations. (E) Aβ1–42 E22G expressing flies showed increased survival for all curcumin concentrations. (F) Survival of Tau expressing flies was unaffected at low and intermediate concentrations of curcumin, but revealed a shortened survival time at the high curcumin concentration. (G) Median survival time of all genotypes with no curcumin added represented in black bars, 1, 10, and 100 µg curcumin per g yeast paste represented in yellow, orange, and red bars respectively. Significance was compared using a paired student's t-test between untreated and treated with curcumin (ns: non-significant; *: P<0.05, **: P<0.01; ***: P<0.001).