Mesenchymal Transition and PDGFRA Amplification/Mutation Are Key Distinct Oncogenic Events in Pediatric Diffuse Intrinsic Pontine Gliomas
Figure 1
DIPG are different from supratentorial high-grade gliomas in children.
Hemispheric, midline/thalamic tumors and DIPG are represented in gold, grey and violet respectively. Panel A: Gene expression of 23 DIPG and 49 supratentorial HGG were compared using a Principal Component Analysis on all 15231 quality control passing probes. Tumors are displayed according to their coordinates on the three first principal components, which describe 29.7% of the variance. Panel B: Heatmap of the 712 most differentially expressed genes between DIPG, midline and hemispheric tumors, selected using the moderated t-test of limma package of Bioconductor. Panel C: Radial plot of the expression of transcription factors and neurogenesis regulators according to the three tumor location, in log2 ratios related to normal brain stem. The zero red line represent the expression level of normal adult brainstem.