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Glycoprotein Hyposialylation Gives Rise to a Nephrotic-Like Syndrome That Is Prevented by Sialic Acid Administration in GNE V572L Point-Mutant Mice

Figure 2

Clinical chemistry tests.

(A) Serum albumin in wt (open diamonds), ht (gray squares), and mt (black triangles) mice at 3 months (n = 4 wt, 2 ht, 6 mt), 6 months (n = 9 wt, 3 ht, 9 mt), and 12–15 months (n = 1 wt, 11 ht, 12 mt). Data of the wt and ht mice are presented in the same column. (B) Urinary albumin/creatinine ratio in wt (open diamonds), ht (gray squares), and mt (black triangles) mice at 3 months (n = 8 wt, 3 ht, 9 mt), 6 months (n = 4 wt, 5 ht, 11 mt), and 12–15 months (n = 5 ht, 5 mt). (C) Serum cystatin C at 3 months (n = 4 wt, 2 ht, 6 mt), 6 months (n = 6 wt, 1 ht, 6 mt), and 12–15 months (n = 1 wt, 5 ht, 6 mt). (D) SDS-PAGE analysis of urinary proteins in ht and mt mice at 10 days after birth; 8 µl of urine was separated by SDS-PAGE and stained by CBB. Arrowhead: albumin band (60 kDa). Results are shown as means (bars) with individual data points (A, B, C). *P<0.05, **P<0.01 (Mann-Whitney U-test).

Figure 2

doi: https://doi.org/10.1371/journal.pone.0029873.g002