Dichotomy of Tyrosine Hydroxylase and Dopamine Regulation between Somatodendritic and Terminal Field Areas of Nigrostriatal and Mesoaccumbens Pathways
Figure 10
Phosphorylation stoichiometry in aging.
A. ser19 phosphorylation stoichiometry. Striatum: (ANOVA, p = 0.96, ns). Substantia nigra: (ANOVA, p<0.003, F = 11.1, post-hoc: 6 months vs. 18 months, *p<0.05; 6 months vs. 24 months, *p<0.01). Nucleus accumbens: (ANOVA, p<0.005, F = 9.6, post-hoc: 6 months v 18 months, *p<0.01; 6 months v 24 months, *p<0.05). Ventral tegmental area:(ANOVA, p<0.003, F = 10.9, post-hoc: 6 months v 18 months, ns; 6 months v 24 months, *p<0.05). B. ser31phosphorylation stoichiometry. Striatum: (ANOVA, p = 0.06, ns). Substantia nigra: (ANOVA, p<0.004, F = 10.0, post-hoc: 6 months vs. 18 months, *p<0.05; 6 months vs. 24 months, *p<0.01). Nucleus accumbens: (ANOVA, p<0.03, F = 5.3, post-hoc: 6 months v 18 months, *p<0.05; 6 months v 24 months, ns). Ventral tegmental area: (ANOVA, p<0.01, F = 7.6, post-hoc: 6 months v 18 months, ns; 6 months v 24 months,ns; 18 months v 24 months, *p<0.01). C. ser40phosphorylation stoichiometry. Striatum: (ANOVA, p = 0.27, ns). Substantia nigra: (ANOVA, p<0.01, F = 8.8, post-hoc: 6 months vs. 18 months, *p<0.01; 6 months vs. 24 months, *p<0.05. Nucleus accumbens: ANOVA, p = 0.51, ns. Ventral tegmental area: (ANOVA, p<0.004, F = 10.2, post-hoc: 6 months v 18 months, *p<0.05; 6 months v 24 months,*p<0.01).