Icariin and its Derivative Icariside II Extend Healthspan via Insulin/IGF-1 Pathway in C. elegans
Figure 5
Icariside II may not function as DR mimetic.
Survival curves of A. eat-2 (ad1113), B. rsks-1 (ok1255) hermaphrodites treated with DMSO control or 20 uM Icariside II is shown. Icariside II treatment caused similar lifespan extension in these mutants as in N2 animals. This is the representative of 2 independent experiments. Detailed parameters are presented in Table S3.