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Local Ischemia and Increased Expression of Vascular Endothelial Growth Factor Following Ocular Dissemination of Mycobacterium tuberculosis

Figure 4

Chorioretinal hemorrhage and attenuated vasculature in the eyes of Mtb-infected guinea pigs.

A and B. Fundus photographs of the posterior pole of the right eye in two uninfected guinea pigs. Arrow heads point to the optic nerve. Note pattern of choroidal circulation. C. Fundus photo of peripheral retina of the left eye of an infected guinea pig on Day 56. Arrows indicate chorioretinal hemorrhages. Note attenuation of choroidal vessels and creamy deep choroidal lesion with overlying vessels (arrow head); this lesion likely represents a choroidal granuloma. D. Posterior pole fundus photograph of left eye of an infected guinea pig on Day 56. An arrow head points to the optic nerve. Arrows point to hemorrhages. Note attenuated choroidal vasculature.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0028383.g004