Characterization of PTZ-Induced Seizure Susceptibility in a Down Syndrome Mouse Model That Overexpresses CSTB
Figure 3
Locomotor activity of 2n, Ts and Tt mice and histological analysis of the cerebellum.
(a) and (b) Mean ± SEM for the total distance travelled and the number of rears during the 30 min session in the open field. (c) Mean ± SEM for the latency to fall from the ratorod. (d) Hematoxylin/eosin-stained coronal sections in through the cerebellum of 6 month-old 2n, Ts and Tt mice (×1,25 and ×40 magnifications) showing similar granular cell layers for the different mice. The position of the enlarged zone in the higher magnifications is shown by the boxes in the top panel.