Characterization of Natural Killer Cell Phenotype and Function during Recurrent Human HSV-2 Infection
Figure 2
KIR expression on NK cells from symptomatic HSV-2 patients.
(A) Representative stainings for KIR2DL1-, KIR2DL3-, and KIR3DL1-positive CD56dim NK cells from one patient with recurrent HSV-2 infection. (B) KIR expression on CD56dim NK cells. (C) Frequency of CD56dim NK cells expressing 0, 1, 2, or 3 KIRs, as determined after a Boolean gating analysis for KIR2DL1, KIR2DL2/3, and KIR3DL1. In (B) and (C), closed circles represent asymptomatic (AS) HSV-2 seropositive individuals (n = 6) and open circles represent patients with recurrent (S) HSV-2 infection (n = 9). In (B) and (C), the Mann-Whitney rank sum test was used, n.s., not significant, bars represent means.