A Two-Compartment Model of VEGF Distribution in the Mouse
Figure 3
Model parameters were optimized computationally to fit simulation results (solid lines) to experimental data (open circles) [16] for the concentration profiles of the unbound VEGF Trap and the VEGF/VEGF Trap complex. VEGF Trap was injected intravenously (into the blood compartment) at (A) 1 mg/kg, (B) 2.5 mg/kg, (C) 10 mg/kg, and (D) 25 mg/kg.