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Maternal Immunization with Pneumococcal Surface Protein A Protects against Pneumococcal Infections among Derived Offspring

Figure 7

Protection against fatal systemic pneumococcal infections by maternal immunization with PspA among offspring.

Offspring at 10-days of age were intraperitonally challenged with 1×104 CFU TIGR4 strain (100 µl/mouse) with anesthesia. After challenge, offspring were monitored for 5 days to determine survival. Group A (n = 24), B (n = 28), C (n = 24), and D (n = 38) mice were produced in the same manner as the corresponding groups in figure 3. Group A mice are offspring delivered from PspA-immunized mothers and breast-fed by the same mothers (n = 24). Group B mice are offspring from sham-immunized mothers and breast-fed by PspA-immunized mothers (n = 28). Group C mice are offspring from PspA-immunized mothers and breast-fed by sham-immunized mothers (n = 24). Group D mice are offspring from sham-immunized mothers and breast-fed by the same mothers (n = 38). * p<0.01 when compared with control offspring in Group D by Kaplan-Meier test with Log rank test.

Figure 7

doi: https://doi.org/10.1371/journal.pone.0027102.g007