< Back to Article

Reversal of Fragile X Phenotypes by Manipulation of AβPP/Aβ Levels in Fmr1^KO Mice

Figure 1

AGS are rescued by genetic manipulation of App or mGluR₅ blockade.

(A) western blot analyses of AβPP levels in Fmr1^KO, WT, App^HET and Fmr1^KO/App^HET mice (n = 3 male mice per strain, 1 month old). Statistics: one-way ANOVA p<0.0001, F = 53.95. Stars (★) denote statistically different levels by Student T-test analyses and by Bonferroni's multiple comparison test (p<0.05). Error bars represent SEM. (B) Assessment of WR, AGS and death rates in Fmr1^KO mice (age P21, n = 58)) after genetic manipulation of AβPP levels (n = 23) or treatment with MPEP (n = 14). Stars (★) denote rates that are statistically different from untreated mice (p<0.5) by Fisher exact tests.

doi: https://doi.org/10.1371/journal.pone.0026549.g001