Transgenic Expression of Entire Hepatitis B Virus in Mice Induces Hepatocarcinogenesis Independent of Chronic Liver Injury
Figure 4
Increase in incidence of hepatocellular tumors in the Mutant 1 and wildtype HBV transgenic mice.
Incidence of all hepatocellular tumors (All) and HCC, shown as a percentage of mice with tumor, is from 33 non-transgenic, 19 Mutant 1-Line 4, 30 Mutant 1-Line 7, and 20 Tg05 wildtype HBV male mice. The non-transgenic mice are the littermates of Mutant 1-Line 4, Line 7, or Tg05 mice and because they have comparable tumor incidence, they are grouped together here. Significant differences between the transgenic and non-transgenic mice are indicated by one (P<0.05) or two (P<0.01) asterisks.