Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes
Figure 6
Model for a bacterial role in gut integrity leading to either a healthy state or autoimmunity for type 1 diabetes.
In this model, the fate of lactate is crucial in determining gut health. Conversion to butyrate results in more mucin synthesis and tighter junctions. Conversion to other short chain fatty acids (SCHAs) reduces mucin synthesis and tight junctions. Bacterial genera listed are examples of a given phenotype. Other bacteria may also be involved in these characteristics.