Protective Contributions against Invasive Streptococcus pneumoniae Pneumonia of Antibody and Th17-Cell Responses to Nasopharyngeal Colonisation
Figure 7
Role of antibody in the effect of prior colonisation on subsequent pneumonia.
(A) Bacterial cfu in BALF, lung and blood of colonised or control μMT mice 18 h following pneumonia challenge. (B) Bacterial cfu in BALF, lung and blood of passively immunised CBA/Ca mice 18 h following pneumonia challenge. Mice received pooled serum collected from either colonised or control CBA/Ca mice prior to challenge. Each symbol represents results for an individual mouse and bars the median for each group. The dotted line is the limit of detection. Lung cfu are compared between groups by Mann-Whitney U-test. Presence or absence of bacteraemia was assessed by Fisher exact test.