Skip to main content
Advertisement
Browse Subject Areas
?

Click through the PLOS taxonomy to find articles in your field.

For more information about PLOS Subject Areas, click here.

< Back to Article

Robustness Analysis and Behavior Discrimination in Enzymatic Reaction Networks

Figure 3

Profile of second enzyme (MMP2) production.

We focus here on the activation cascade of pro-MMP2 enzyme, i.e., we exclude shedding and collagen degradation from the model. The initial concentrations of MMP-MT1 is 60 nM and initial pro-MMP2 is 50 nM, which explains the qualitative switch in C for initial TIMP2 greater than 50 nm. A Activated pro-MMP2 in percentage of initial quantity after different fixed times - the curve corresponding to 12 hours reproduces a result from [23]. The asymptotic behavior for times going to is, as suggested by the curve corresponding to 1000 hours, a linear activation from 0 to 50 nM and a plateau at 100 activation for initial TIMP250 nM. B Activated MMP2 after the variation of MMP2 has reached different low rates. For initial concentration of TIMP2160 nM, the activation rate is never above , hence the percentage is 0. C Time after when the variation of MMP2 has reached the different low rates. The non-monotonic behavior for per hour above 50 nM suggests there is an optimum value for which activation is eventually (asymptotically) complete while the speed of the process at its beginning is maximized.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0024246.g003