Sequencing of DISC1 Pathway Genes Reveals Increased Burden of Rare Missense Variants in Schizophrenia Patients from a Northern Swedish Population
Figure 1
Prevalence of intrinsic disorder in the studied DISC1 pathway proteins, as measured by DisProt analysis.
(A) Disorder content of the individual proteins of the DISC1 pathway (i.e. percentage of disordered residues/ total number of amino acids). (B) Disorder content of the DISC1 pathway proteins compared to human proteome (i.e. 20320 SwissProt proteins), a set of brain proteins (7160 sequences from GeneAtlas) and a set of schizophrenia candidate proteins (670 sequences from the Schizophrenia Gene Resource database). Overall, the DISC1 pathway proteins exhibit a higher abundance of intrinsically disordered residues, compared to the human proteome.