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Gut Microbiota Dysbiosis Is Associated with Inflammation and Bacterial Translocation in Mice with CCl4-Induced Fibrosis

Figure 4

Pro-inflammatory cytokine profile along the study protocol.

(A) TNF-α and IL-6 serum levels in control (n = 4/week) and treated mice (n = 6/week). Values, measured by cytometric bead arrays, obtained from each single mouse at different study weeks are represented in the Figure. *p<0.05 compared with the weekly control group. (B) Correlation between serum TNF-α and IL-6 with C. coccoides counts from samples of intestinal cecum content in all control (n = 22) and treated mice (n = 24) included in the study. (C) Correlation between serum TNF-α and IL-6 with C. leptum counts from samples of intestinal cecum content in all control (n = 22) and treated mice (n = 24) included in the study.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0023037.g004