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The Impact of Utilizing Different Optical Coherence Tomography Devices for Clinical Purposes and in Multiple Sclerosis Trials

Figure 4

Agreement between Spectralis OCT and Cirrus HD-OCT measures of RNFL thickness and TMV.

Bland-Altman plots show low mean differences (solid lines) indicating good agreement on average across studied cohorts, but with wide LOA (dotted lines) indicating poor agreement at an individual patient/subject level between Spectralis and Cirrus HD-OCT derived measures of RNFL thickness in RRMS (4a) and healthy control (4b) eyes and measures of TMV in RRMS (4d) and healthy control (4e) eyes. On average, Spectralis measured higher values of RNFL thickness and TMV than Cirrus HD-OCT. Analysis of the mean differences between Spectralis and Cirrus HD-OCT by quartile revealed consistent variability between machines with respect to RNFL thickness (4c) and TMV (4f) measures.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0022947.g004