Four Small Puzzles That Rosetta Doesn't Solve
Figure 1
Small “puzzles” for high resolution Rosetta tests.
(A) Trp cage, (B) α-conotoxin GI, (C) Reactive loop of chymotrypsin inhibitor from barley, (D) the UUCG tetraloop (RNA). Each panel shows experimental structures side-by-side with lowest energy Rosetta de novo model discovered in extensive runs (see Fig. 2 and Table 1).