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Estimating the Threshold Surface Density of Gp120-CCR5 Complexes Necessary for HIV-1 Envelope-Mediated Cell-Cell Fusion

Figure 2

Model predictions of cell-cell fusion in the absence of a coreceptor antagonist.

A) Distribution, f(C0), of the CCR5 expression level, C0, across cells, predicted using Eq. (12), for the mean expression, and different values of the standard deviation, . Inset: Fraction of cells fused, F, is the (shaded) area under the f(C0) curve for , the threshold CCR5 expression level for fusion. B) F as a function of GCT, the threshold surface density of gp120-CCR5 complexes necessary for fusion. Inset: The dependence of on GCT computed using Eq. (11).

Figure 2

doi: https://doi.org/10.1371/journal.pone.0019941.g002