Transient Gastric Irritation in the Neonatal Rats Leads to Changes in Hypothalamic CRF Expression, Depression- and Anxiety-Like Behavior as Adults
Figure 2
The effect of neonatal IA treatment on psychological behavior of adult rats (continued).
A. Open field test. i. The total distance traveled (cm) in the 30-minute test time. ii. The percentage time spent in center. There was a significant decrease in the time that IA-treated rats spent in the center as well as the total distance traveled. Data represent the mean ± SEM of 20 rats per group. B. Light dark box test. i. The percent of time spent in the light box was significantly shorter in the IA-treated rats as compared with control rats. ii. The number of light-dark box transitions was not significantly different between the two groups (n = 10 per group). (* = Significantly different from control group).