Cognitive and Socio-Emotional Deficits in Platelet-Derived Growth Factor Receptor-β Gene Knockout Mice
Figure 5
Locomotor activities (A) and spatial performance (B) in the food search test.
A: Locomotor activities during the dark and light phases of each experimental day (a) and mean locomotor activities during the dark and light phases of the 4 experimental days (b). The PDGFR-β KO mice displayed significantly higher locomotor activities than the control mice [F(1, 18) = 5.028; p<0.05; control, n = 10; KO, n = 10] (a). Mean locomotor activity was also significantly higher in the PDGFR-β KO mice than the control mice during dark and light phases (Student's t-test, p<0.05) (b). Vertical axis indicates number of crossing beams. B: Mean correct ratios of each experimental day (a) and each hour after changing the position of the accessible food station (b). The PDGFR-β KO mice displayed significantly higher correct ratios in (a) [F(1, 18) = 16.257; p<0.001; control, n = 10; KO, n = 10] across the 4 days and (b) [F(1, 18) = 8.536; p<0.01; control, n = 10; KO, n = 10] at 3rd and 4th hr. Filled circles, PDGFR-β KO mice; open circles, control mice. *, p<0.05; **, p<0.01; ***, p<0.001.