Increased Breadth and Depth of Cytotoxic T Lymphocytes Responses against HIV-1-B Nef by Inclusion of Epitope Variant Sequences
Figure 2
Distribution of reactive consensus and variant 10-mer peptides.
Colored blocks correspond to the 10-mers that were recognized, while the 10-mers that were tested are outlined in black. Recognition of peptides is figured using a gradient of colors: consensus peptides are figured in burgundy and variant peptides follow a gradient from the most conserved (in orange) to the most rare (in purple), while peptides not found in a database of 514 sequences are in black. Each block represents the start position of the 10-mers based on their HXB2 coordinates. Panel A shows all the peptides recognized, panel B represents for each individual only the most frequent peptide recognized at each position (i.e., if an individual recognized the consensus peptide and variants 1 and 4, only the recognition through the consensus is figured).