Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease
Figure 1
Dendritic spine analysis in Tg2576 mice and wildtype littermates.
(A) Tg2576 animals have deficits in apical dendritic spine density at both four (n = 4) and fourteen (n = 5) months of age, as compared to WT mice (n = 4 at four months; n = 5 at fourteen months), that are reversed by short-term (11 days) PBT2-treatment (n = 3 at both age points). There are also age-related decreases in apical spine density in both the Tg groups. (B) There is a significant increase in basal spine density in fourteen month old Tg animals treated with PBT2. There is also an age-related decrease in basal spine density in WT animals. (C) There were no significant differences in apical or basal dendrite number across the experiment. (D) There were no significant differences in apical or basal dendrite length across the experiment. Values are mean ± SEM. **p<0.01, ***p<0.001.