Adenylate Cyclase Toxin Promotes Internalisation of Integrins and Raft Components and Decreases Macrophage Adhesion Capacity
Figure 5
Calpain is involved in the endocytosis triggered by ACT
. Cell pre-incubation with calpeptin (50 µM) inhibits calcium influx mediated by ACT (A) and the internalisation of the integrins (B). Internalisation and Ca2+ influx were determined as described in Materials and Methods. Data shown are the mean ± SEM of at least three independent experiments, with *p<0.05 and ***p<0.001.