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Sildenafil Reduces Insulin-Resistance in Human Endothelial Cells

Figure 3

eNOS Ser1177 phosphorylation after sildenafil treatment.

Sildenafil chronic treatment (1 µM/72 h) enhances eNOS phosphorylation in basal condition and after HG treatment, but not significantly after Gluc-N treatment. Full bars represent conditions without sildenafil, dashed bars represent sildenafil treatment. Ctrl was expressed as 100%. Means ± S.E. (n = 5). *p<0.05 vs Ctrl, ‡ p<0.05 vs insulin; † p<0.05 vs HG; †† p<0.05 vs HG + insulin.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0014542.g003