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A Transcription Factor Map as Revealed by a Genome-Wide Gene Expression Analysis of Whole-Blood mRNA Transcriptome in Multiple Sclerosis

Figure 13

Correlation plot for the insulin receptor star centre (INSR).

The figure shows the correlation of scaled expression values of INSR (insulin receptor, purple line) with the average of negatively (left column) and positively (right column) correlated neighbour probes (coloured dots). The light blue vertical line separates control samples to the left and MS to the right. The figures show three different orderings: by the harmonic mean of neighbours (top row), by the star centre expression value (middle row) and by the difference between star centre and neighbours average (bottom row). The class correlation values of star centre with neighbours are shown in the top figure; for example, r(−,C) is correlation coefficient of negatively correlated probes with control samples and r(+,MS) is the correlation of positively correlated probes with MS samples. Dot colours indicate sample class: green – control, blue – PPMS, red – RRMS, yellow – SPMS. This graph illustrate patterns of differential co-expression in Control versus MS samples. In particular, on the left it can be observed that some neighbours are strongly anti-correlated with the star centre in controls (correlation coefficient −0.744) but weakly correlated in MS (0.130); on the right, the remaining neighbours are strongly correlated with the centre in controls (0.739) but weakly anti-correlated in MS (−0.233).

Figure 13

doi: https://doi.org/10.1371/journal.pone.0014176.g013