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Systematical Detection of Significant Genes in Microarray Data by Incorporating Gene Interaction Relationship in Biological Systems

Figure 1

False positive rate of T-test, F-test, Fold-change, SAM(0.3), and SWang with 5 samples for both case and control from Normal distribution.

A: False positive rate of SWang(1,2) and other methods. B: False positive rate of SWang(1,3) and other methods. C: False positive rate of SWang(1,4) and other methods. D: False positive rate of SWang(2,3) and other methods. E: False positive rate of SWang(2,4) and other methods. F: False positive rate of SWang(1,3) and other methods. The false positive rate of T-test(black spotline), F-test(gray spotline), Fold change(not shown), SWang(blue spotline), and SAM(0.3)(not shown) with cutoff of p-value. Note that the curves of SAM and Fold-change cannot be drawn due to false positive rate of SAM and Fold-change that can not calculated, as all real DEGs are considered as non-DEGs under both methods.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0013721.g001