Molecular Biomarker Analyses Using Circulating Tumor Cells
Figure 5
EGFR expression and HER2 status in CTCs from metastatic cancer patients.
A. EGFR scoring in CTCs from metastatic lung cancer patient samples, scored according to criteria described in Figure 2B. B. CTC counts from 39 metastatic breast cancer patient samples listed by subtype. C. HER2 IF scoring criteria showing the high and low range of expression. D. Quantification of HER2 scoring in CTCs. H-score for HER2 IF in CTCs, HER2 status in patient tumor, CTC counts and HER2 FISH results in CTCs are listed in table below. HER2 FISH was performed on CellSearch (CS) or on the OncoCEE microchannel (OncoCEE). For HER2 FISH, (+) indicates a positive FISH result, (-) indicates a negative result and (f) indicates that the FISH failed because no CTCs were detected.