Selenoproteins Are Essential for Proper Keratinocyte Function and Skin Development
Figure 4
Progressive epithelial dysfunction and aberrant follicular morphogenesis in knockout mice.
(A–P) Back skin sections from control (A, C, E, G, I, K, M, O) and knockout mice (B, D, F, H, J, L, N) were stained with H&E for histological examination. Thickened cornified layer (arrow), hyperplastic epidermis (asterisk) and detachment along dermal–epidermal junction (arrowhead) along with decrease in fat cells (triangle) is evident in knockout mice. Defective hair follicle morphogenesis in mutant skin is characterized by irregularly spaced malformed hair follicles. Scale bars: 100 µm.