Environmental Exposure of the Mouse Germ Line: DNA Adducts in Spermatozoa and Formation of De Novo Mutations during Spermatogenesis
Figure 4
Mutation frequencies in the liver of Big Blue® mice exposed to B[a]P.
The Mf values are given as means (per 106 pfu) ±SE, and the days of sacrifice are indicated on the x-axis. Mice sacrificed at day 0 are untreated controls. Treatments groups and number of mice (n) are given: 0 days untreated (n = 3); 4 days B[a]P (n = 4); 16 days B[a]P (n = 6); 30 days B[a]P (n = 5); 44 days B[a]P (n = 6); 120 days B[a]P (n = 6) and 120 days corn oil (n = 6). Statistically significant differences (Mann-Whitney) between the Mf of the groups and p-values are indicated.