Switch from Stress Response to Homeobox Transcription Factors in Adipose Tissue After Profound Fat Loss
Figure 2
Functional categorization of differentially expressed genes in subcutaneous adipose tissue after fat loss (Biological Process).
PANTHER was used to search for over-represented Biological Process categories among the most differentially expressed genes (q-value = 0, fold change ≥1.5), comparing adipose tissue before versus after bariatric surgery (n = 16) and versus controls (n = 13). The color intensity displays the statistical significance (−log p-value) of over- and under-represented PANTHER functional categories. A p-value<0.01 with Bonferroni correction for multiple testing was used as inclusion criterion for categories. Numbers presented in the table indicate the percentage of genes within a gene set that map to the given category, e.g. 18% of the 469 down-regulated genes map to the biological process ‘Immunity and defense’. The first column states the overall distribution of a term among all human NCBI genes (25,431), e.g. 5% of the genes are expected to map to ‘Immunity and defense’, hence this category is significantly over-represented among the down-regulated genes. Ref, reference (based on all human NCBI genes); Pre, pre-surgery biopsies; Post, post-surgery biopsies; Ctr, biopsies of lean controls; Arrow up, up-regulated/more expressed genes; Arrow down, down-regulated/less expressed genes.