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Sensitive Detection of Gene Expression in Mycobacteria under Replicating and Non-Replicating Conditions Using Optimized Far-Red Reporters

Figure 10

Virulence of M. tuberculosis fluorescent strains in murine macrophages.

Murine macrophages were infected at an MOI of 1∶1 with recombinant strains expressing the indicated reporter from Psmyc. Bacterial counts were measured over a period of 7 days. Data are the mean and standard deviation from three independent infections. Time points for each reporter strain, from left to right are day 1, day 3 and day 7.

Figure 10

doi: https://doi.org/10.1371/journal.pone.0009823.g010