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Dissecting Interferon-Induced Transcriptional Programs in Human Peripheral Blood Cells

Figure 5

The transcriptional plasticity of immune cellular responses to IFNγ stimulation.

79 genes associated with a single isolated immune cell subtype (without stimulation) were induced after IFNγ treatment in other cell types. Genes defined as cell type-associated (by comparing unstimulated time series, as detailed in Figure 3A) are marked on the left. The top panel detailing B cell associated genes, followed by T cell, NK cell, and monocyte associated genes illustrated in the bottom panel. The differential regulation of these genes after IFNγ treatment in each cell type (as in Figure 3B) is described on the right. The expression profiles are ordered by hierarchical clustering; the genes are displayed as rows, cell type/time points as columns. Red coloring in the cell-type associated panels (on left) signifies highly expressed in a single cell type compared to all other cell types; blue coloring denotes low expression. Red coloring in the IFNγ responsive panels (on right) signifies up-regulation, and blue coloring signifies down-regulation of expression after IFNγ exposure relative to the mock-treated discrete cell population. B (B cells); T4 (CD4+ T cells); T8 (CD8+ T cells); NK (NK cells); M (monocytes). The column marked SAM details (in red) which genes were significantly differentially expressed by IFNγ in each cell type. Genes are marked as annotated in Source [73].

Figure 5

doi: https://doi.org/10.1371/journal.pone.0009753.g005