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A Novel Probiotic Mixture Exerts a Therapeutic Effect on Experimental Autoimmune Encephalomyelitis Mediated by IL-10 Producing Regulatory T Cells

Figure 2

L. paracasei reduces secretion of pro-inflammatory and promotes secretion of anti-inflammatory cytokines in EAE mice.

(A–E) Spleen cell cultures from probiotic-treated or control mice were restimulated in vitro with MOG35–55 peptide, supernatants were collected and the levels of pro-inflammatory Th1 cytokines, TNF-α and IFN-γ, and Th2 cytokines, IL-4, IL-10 and TGF-β1, were determined using ELISA kits. Data are representative of two experiments. Each bar represents mean ± SEM of three samples per group. * represents a p-value ≤0,05 and ** a p-value ≤0,01.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0009009.g002