Acute Stress Increases Depolarization-Evoked Glutamate Release in the Rat Prefrontal/Frontal Cortex: The Dampening Action of Antidepressants
Figure 2
Effect of chronic antidepressant treatments on depolarization-evoked release of amino acid neurotransmitters from prefrontal/frontal cortex synaptosomes.
A) 15 mM KCl evoked glutamate and GABA release from P/FC synaptosomes of vehicle-treated (CNT), chronically treated with fluoxetine (FLX), subjected to FS-stress (STRESS) or chronically treated with FLX and then subjected to FS-stress (FLX+STRESS) rats. Data are expressed as means±SEM. *p<0.05, Newman-Keuls post-hoc tests following one-way ANOVA (n = 6–9 rats/group). B) 15 mM KCl evoked glutamate and GABA release from P/FC synaptosomes of vehicle-treated (CNT), chronically treated with desipramine (DMI), subjected to FS-stress (STRESS) or chronically treated with DMI and then subjected to FS-stress (DMI+STRESS) rats. Data are as in A. *p<0.05, statistics as above. C) 15 mM KCl evoked glutamate and GABA release from P/FC synaptosomes of vehicle-treated (CNT), chronically treated with venlafaxine (VFX), subjected to FS-stress (STRESS) or chronically treated with VFX and then subjected to FS-stress (VFX+STRESS) rats. Data are as in A. *p<0.05; **p<0.01, statistics as above. D) 15 mM KCl evoked glutamate and GABA release from P/FC synaptosomes of vehicle-treated (CNT), chronically treated with agomelatine (AGO), subjected to FS-stress (STRESS) or chronically treated with AGO and then subjected to FS-stress (AGO+STRESS) rats. Data are as in A. **p<0.01, statistics as above.