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Pseudomonas aeruginosa Exploits Lipid A and Muropeptides Modification as a Strategy to Lower Innate Immunity during Cystic Fibrosis Lung Infection

Figure 1

Chemical structure of P. aeruginosa lipid A.

MALDI MS spectra of lipid A blend obtained by acid hydrolysis of LPS from P. aeruginosa clinical strains isolated at the onset of chronic colonization (AA2) (A) and after years of chronic infection (AA43 and AA44) from a CF patient (B and C). A difference of 238 Da corresponds to a 16∶0 fatty acid residue whereas 170 corresponds to a 10∶0 (3-OH) residue and 80 Da are indicative of a phosphate group. The 16 Da difference is relative to the presence of a Hydroxy group at C-2 of the secondary 12∶0 fatty acids. The non indicated ion peaks are relative to the species already indicated and bearing sodium or potassium counter-ions.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0008439.g001