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Dynamic Near-Infrared Optical Imaging of 2-Deoxyglucose Uptake by Intracranial Glioma of Athymic Mice

Figure 2

In vivo real-time near infrared imaging of a mouse.

A series of whole body images was acquired before and after injection of near infrared dye labeled 2-DG, IRDye800CW 2-DG, via a mouse tail vein. Selected images captured the first pass perfusion of the dye into various internal organs: heart and lung area at 1.2 s, brain and upper limbs at 2.5 s, kidney at 4.5 s, etc. Principal Component Analysis of the kinetics was used to identify tissue regions based on DyCE software as shown in the color presentation (top left) and representative time courses (bottom right).

Figure 2

doi: https://doi.org/10.1371/journal.pone.0008051.g002