Determining Protein Complex Connectivity Using a Probabilistic Deletion Network Derived from Quantitative Proteomics
Figure 1
Hierarchical clustering on the wild-type purifications.
A hierarchical cluster was performed on the relative protein abundances expressed as dNSAFs. Each column represents an isolated purification, and each row represents an individual protein (prey). The color intensity represents protein abundance with the brightest yellow indicating highest abundance and decreasing intensity indicating decreasing abundance. Black indicates that the protein was not detected in a particular purification. The components of the RPD3L are colored in red, the components of the RPD3S complex are colored in blue, Ash1 and Ume6 are colored in dark red, and Cti6 is colored in light brown. The shared module is colored in orange.