Interleukin-10 Overexpression Promotes Fas-Ligand-Dependent Chronic Macrophage-Mediated Demyelinating Polyneuropathy
Figure 2
IL-10 gene and protein expression in VMD2-IL-10 transgenic mice.
A, Gene expression of IL-10 is upregulated in the eye, testes, brain, sciatic nerve, and spinal cord of Tg+ sick animals compared to tissues from Tg− littermates, as determined by quantitative real-time RT-PCR. B, IL-10 protein levels from the cerebrospinal fluid (CSF) significantly increase in correlation with disease progression (p≤0.002 for each stage of disease), as determined by IL-10 specific ELISA. Plasma levels of IL-10 are not elevated in Tg+ mice.