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Assessing the Contribution of Heme-Iron Acquisition to Staphylococcus aureus Pneumonia Using Computed Tomography

Figure 2

The contribution of heme acquisition to the virulence of S. aureus.

(A): Bacterial burden and CT imaging of S. aureus wild type vs. S. aureus ΔisdBH pneumonia at 24 hours post infection. The horizontal bar represents the average bacterial burden in colony forming units of homogenized lung tissue with the boxes representing the standard deviation of the sample population. Sample sizes are indicated below each bar. (B): Bacterial burden and CT imaging of S. aureus pneumonia at 24 hours post infection with wild type, ΔhtsA or ΔhtsAΔisdE. The horizontal bar in the left most figure represents the average bacterial burden in colony forming units of homogenized lung tissue with the boxes representing the standard deviation of the sample population. Sample sizes are indicated below each sample. (C): Bacterial burden in homogenized lung, heart and kidney in a systemic model of staphylococcal infection comparing S. aureus wild type to S. aureus ΔhtsAΔisdE. Sample sizes are indicated below each bar.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0006668.g002