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A Functional γδTCR/CD3 Complex Distinct from γδT Cells Is Expressed by Human Eosinophils

Figure 9

γδTCR-dependent tumor-cell killing by human eosinophils.

(A–B) Induction of Colo205 killing by eosinophils and inhibition by an anti-γδTCR blocking antibody. Percentage of AnnexinV+ tumor cells in the presence or absence of eosinophils and blocking anti-γδTCR or isotype control antibodies (n = 5–7) at various time-points. Panel A represents the 60 min time-point. (C–D) Potentiation of eosinophil-mediated Colo205 killing by γδTCR ligands. (C) 50 µM SBA (n = 7). (D) 20 mM TUBag (n = 4). *, P<0.05; **, P<0.01.

Figure 9

doi: https://doi.org/10.1371/journal.pone.0005926.g009