STAT1 Pathway Mediates Amplification of Metastatic Potential and Resistance to Therapy
Figure 1
IFN/STAT1 signaling differs between tumor cell lines and is required for suppression of lung colonization.
(A) Number of mice developing lung colonies and total number of lung colonies per mouse in C57BL/6 wild type and IFNγ−/− mice after intravenous injection of B16F1 tumor cells (horizontal line represents mean). (B) Images of wild type and IFNγ−/− explanted lungs demonstrate marked difference in number of lung colonies. (C) Differential response to IFNγ in vitro between B16F1 (parental) and B16F10 (passaged, more aggressive) cell lines (mean±SD). (D) Variable fold-induction of IFN/STAT1 marker genes for eight cultured cell lines from P1 passage B16F1 lung colonies in C57BL/6 mice (numbers represent expression scores).