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Rhythmicity in Mice Selected for Extremes in Stress Reactivity: Behavioural, Endocrine and Sleep Changes Resembling Endophenotypes of Major Depression

Figure 4

Diurnal variation of immunoreactive corticosterone metabolites (CM) in faecal samples of high (HR), intermediate (IR), and low (LR) reactivity males from generation VII over the 24-h light-dark cycle.

Data are given as means±SEM for each line. Statistical differences between the three lines are indicated by asterisks (KWH-tests, for details see text, p<0.05 *, p<0.01 **, p<0.001 ***). The dark phase of the light-dark cycle is indicated by the shaded area.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0004325.g004