A Novel Replication-Competent Vaccinia Vector MVTT Is Superior to MVA for Inducing High Levels of Neutralizing Antibody via Mucosal Vaccination
Figure 4
Anti-S-specific Nab response in mice vaccinated with MVA-S (A) or MVTT-S (B) via various routes.
Groups of 3 mice were inoculated with 105 PFU MVTT-S or MVA-S twice at a three-week interval via seven different routes including i.m., i.d., s.c., i.o., i.n., i.r. and i.p. The sera were collected two weeks after the last injection and subjected to the neutralization assay. The Y axis stands for the percentage of inhibition while the X axis represents the serum dilution factor. The dash line indicates the level of 50% of viral inhibition. The experiment was repeated twice with similar results obtained.