Validating Discovered Cis-Acting Regulatory Genetic Variants: Application of an Allele Specific Expression Approach to HapMap Populations
Figure 2
Statistical model for the detection of cis-acting variants.
We applied a linear regression (LR) model ((similar to that of Teare et al[13]) to assess whether there was evidence of linear relationship between the allelic expression ratio of the phased heterozygous type 1 (TC/TA, group 1), combined homozygous types (TT/TA or CC/TA, group 2), and phased heterozygous type 2 (CT/TA, group 3). We assumed that homozygous types group will have no allelic imbalances.