Protective Antiviral Immunity Conferred by a Nonintegrative Lentiviral Vector-Based Vaccine
Figure 3
A single dose of nonintegrative lentiviral vector coding for EWNV elicits a strong and specific antibody response.
Groups of adult mice (n = 6) were immunized intraperitoneally with graded doses (1–100 ng of p24 antigen) of TRIP.NI EWNV or TRIP.I EWNV particles. Control mice were inoculated with 100 ng of heat-inactivated (HI) particles. After 21days, pooled sera (6 mice per group) were assessed for the presence of WNV-specific antibodies. Data are representative of three independent experiments.